Adenomyosis on the Endometriosis Spectrum — Part 1

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Full transcript of the original video, lightly edited for readability.

Endometriosis is a spectrum disease. It's now official, according to an article that came out May 2026, and for some April 2026, there was a worldwide genetics study. But here's the thing, we have been postulating this back in 2022. So let's talk about this. We have been saying for a very, very long time that endometriosis is a spectrum of phenotypes. We actually have a video that goes back into January that talks about this. It's a spectrum. Adenomyosis fell in that spectrum. We have been saying for years and years and years that this is not two separate conditions.

It is a singular condition, a spectrum. Now let's talk about the study. This was a new multi ancestry, genome wide association and multiomics study showing exactly why this matters, why this idea is important. The study looked at approximately 1.4 million women, including over 105,000 cases of endometriosis and adenomyosis. They found 80 genomic regions associated with endometriosis risk. They also found what was associated with adenomyosis and endometriosis. This includes transcript transcriptomics, epigenetics, genetic risks and various other pathways and gene and the genetic alterations associated.

There was a focus on cell differentiation, immune regulation, hormone regulation, tissue remodeling, inflammation, etc. Pretty much what makes endometriosis endometriosis. They looked at why certain symptoms occurred. For example, abdominal pain or maybe on this side, anxiety or there's a comorbidity where there's a broad, the worst of the worst cases from, you know, thoracic endometriosis to bowel problems to psychiatric issues and Now we have actual proof. We've been saying this again since 2022, but now there's an actual study that has put everything that we have compiled into one clean study.

So let's. Let's explain what this actually means, okay? How. How is it in a spectrum? Let's think of jeans like a shoelace. This isn't a shoelace. But again, let's. Let's think of one long shoelace. Now, imagine that the shoelace runs through various parts of what is endometriosis. This is your endometriosis. Mutations that the reason why you suffer. This portion might be immune. This portion might be blood vessels. This might be tissue remodeling, adhesions, fibrosis, severe pain due to sensory, nerves. And maybe we see bowel here, so on and so forth.

Depending where that variation falls in, the shoelace is what you will see as your phenotype. We have talked about this, and we have made videos about this. If you are here, you might be more hormone responsive, more estrogen sensitive. If you fall right here, maybe you have more progesterone resistance. That variation really is going to affect how you have to look at endometriosis. Your phenotype maybe more inflammatory, so you. You flare super quick. Maybe over here, your mast cell activated. So the phenotype or the.

The way your endometriosis represent itself is highly dependent on which mutations you're gonna find. There is a basis, there is a root, but overall, how you see it. That's why we can have a Stage 4 and be highly adhesive, highly infiltrating, but no sensory pain. But we can have stage one and 2 on this side, and you have maybe a couple red vesicle lesions, and you are an excruciating and severe pain. That is why it all gets explained. So again, if you want to understand what this study means, you must think of it like a shoelace.

This is the endometriosis gene, if you will. And this is overly simplified, mind you. There's. We can get much, much more complicated. But for the sake of this video and explanation, this is what this study means. Depending on where you fall, this is what is going to be the endometriosis you deal with.