The early research
Jonathon’s manuscript traces his early formulation thinking to 2015, before ENDOLLS existed as a business.
Our story
It began with family.
It became ENDOLLS.
A personal search for understanding grew into a daily regimen—and a commitment to make the thinking behind it accessible.
The reason behind the research
Before there was a brand,
there was a question.
For founder Jonathon Castillo, endometriosis and adenomyosis were part of family life. Watching his wife navigate symptoms, surgery and the search for answers gave him a deeply personal reason to learn more.
In The Burning Path Ahead, Jonathon describes studying the biology of these conditions while serving in the military, then continuing that work after leaving the service. His questions focused on how inflammation, hormone signaling and the surrounding tissue environment interact.
That search became the starting point for ENDOLLS. The goal was to create a considered daily supplement routine, then give women access to the ingredient information and research behind its development.
How the journey unfolded
Years of questions.
A routine that evolved.
ENDOLLS launches
ENDOLLS went public with Revitalizing+ as its original formula.
Renewal joins the routine
The formulation developed into a two-part daily regimen: Revitalizing+ in the morning and Renewal in the afternoon. Together, they are today’s Advanced Duo.
The Burning Path Ahead
Jonathon brought his perspective and research references together in a book, giving readers a deeper look at the ideas behind ENDOLLS.
A new tool for understanding symptoms
The Endometriosis Quiz joined ENDOLLS in 2024, offering an interactive way to explore symptom patterns and prepare for a conversation with a care team. Explore the quiz →
Developing the next hypothesis
We are preparing a new paper presenting our hypothesis about how endometriosis develops and survives. Planned for release in 2026, it will explain the biological reasoning behind that hypothesis and the questions that remain to be tested.
A clearer place to start
Advanced Duo remains the daily foundation. Ruby Radiance is an optional addition. Ingredient details, research and customer experiences are here to help you make an informed choice.
In his own words
Meet the person
behind the formulation.
Watch Jonathon explain the origins and approach of ENDOLLS.
Our commitment
Personal in our purpose.
Specific in our information.
A simple daily foundation
Two distinct formulas, clear directions and transparent amounts. You should know what belongs in your routine.
Research you can follow
We link to original studies and explain their settings. Ingredient research informs our rationale; it does not prove a treatment effect for Advanced Duo.
People you can hear from
Customer reviews and questions remain part of the conversation. Every experience is personal, and your medical care remains essential.