
Revitalizing+
One capsule in the morning upon waking. A distinct blend that includes rhodiola alongside five other ingredients.
30 capsules · 30 servings
For the woman behind the diagnosis
Meet Advanced Duo: our two-part daily supplement regimen, created with endometriosis in mind. See what’s inside, understand the thinking behind it, and find a clear place to start.
Two capsules daily · 30-day supply · $59.00
Dietary supplement. Not a treatment or cure.

Made for your daily routine
Two complementary formulas, one simple daily regimen.
Advanced Duo brings Revitalizing+ and Renewal together, with every ingredient and amount available to inspect. Start with the white box; Ruby Radiance is an optional addition.
The daily foundation
Revitalizing+ in the morning. Renewal later in the day. Both belong to the main regimen, together in the white box.

One capsule in the morning upon waking. A distinct blend that includes rhodiola alongside five other ingredients.
30 capsules · 30 servings

One capsule in the afternoon or mid-day. A second ingredient profile that includes DIM.
30 capsules · 30 servings
We recommend allowing 3–5 months of consistent use to evaluate whether Advanced Duo fits your routine, with your clinician’s guidance. Some customers report noticing changes sooner; experiences vary and results are not guaranteed.
Follow the directions on your current packaging. Read safety considerations.
What published research tells us about endometriosis. Education, the key components to highlight.
Studies of individual ingredients, with attention to the dose, preparation, and population.
Why ingredients were selected together. A formulation hypothesis, clearly identified as such.
The exact studies and published data used in product approach and development.
Founder and customer observations. Meaningful experiences, you have a voice, it needs to be heard.
Inside the duo
125 mg per capsule
Salidroside research explores cell-stress and inflammatory signaling. See the experiments and the study settings.
Explore rhodiola →150 mg per capsule
Explore the research on smooth-muscle activity, including an experiment with isolated human uterine tissue.
Explore valerian →100 mg per capsule
Discover why estrogen-receptor research depends on concentration and cell context.
Explore DIM →These are ingredient facts and research context, not promised benefits. Read the complete Supplement Facts.

An optional next step
Add-on · Black boxDesigned to complement Advanced Duo, not replace it. Keep the daily duo at the center of your routine and consider this add-on with your care team.
A family experience.
A reason to keep asking questions.
The people behind the formula
Jonathon Castillo founded ENDOLLS after a family experience with endometriosis led him into research and formulation development.
That origin explains why this work matters to us. It does not replace clinical evidence. Our responsibility is to show both the thinking and its limits.
From the ENDOLLS community
Read customer experiences, explore their photos and videos, and hear what their routines have been like.
Individual experiences vary. Reviews describe personal experiences and are not clinical evidence.
Before you decide
Advanced Duo is the main ENDOLLS daily regimen: Revitalizing+ and Renewal together in the white box. Ruby Radiance is an optional add-on in the black box; it does not replace the duo.
One set contains 30 Revitalizing+ capsules and 30 Renewal capsules. At one capsule from each bottle daily, that is a 30-day supply.
No. These are dietary supplements, not treatments or cures. No published randomized controlled trial of the exact Advanced Duo was supplied in our evidence review. Ingredient research and customer experiences do not establish a finished-product treatment effect.
Our current Advanced Duo bottles have white labels and gold caps. They replace the earlier yellow translucent bottles. The photographs on this site show the current packaging.
Do not stop or change prescribed care based on this website. Take the label to a clinician or pharmacist before use, especially if you take medicines or other supplements, have a medical condition, or have surgery planned. See the safety section for more detail.
No. One-time purchase is the default. Where a subscription is available, its current plan and price appear beside the purchase controls. Review its renewal terms before choosing it. Existing customers can manage their subscription here.
We recommend allowing 3–5 months of consistent use to evaluate whether Advanced Duo fits your routine, with your clinician’s guidance. Some customers report noticing changes sooner; experiences vary and results are not guaranteed. Follow the label, and seek advice sooner if symptoms worsen or side effects occur.
Shipping charges and available services appear at checkout. Read our shipping information and return terms before ordering. Contact ENDOLLS if you need help with an order.
Take the questions with you
Label questions, evidence checks, and space to think about your current care. Yours to read and print, without an email gate.
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