The daily foundation: Advanced Duo. The optional addition: Ruby Radiance.

For the woman behind the diagnosis

A daily routine.
A more informed
way forward.

Meet Advanced Duo: our two-part daily supplement regimen, created with endometriosis in mind. See what’s inside, understand the thinking behind it, and find a clear place to start.

Two capsules daily · 30-day supply · $59.00
Dietary supplement. Not a treatment or cure.

Advanced Duo: white box with Renewal and Revitalizing+ bottles, white labels and gold caps
Your daily foundationAdvanced Duo / 01
Focused on this community since 2019Two distinct formulasFull ingredient amountsOne-time purchase available

Made for your daily routine

A considered formula.
A clear place to start.

Two complementary formulas, one simple daily regimen.

Advanced Duo brings Revitalizing+ and Renewal together, with every ingredient and amount available to inspect. Start with the white box; Ruby Radiance is an optional addition.

A tool for your next conversation

Make space for your symptoms.

Our Endometriosis Quiz helps you explore symptom patterns and prepare questions for your care team.

The interactive assessment includes surgical history and a downloadable summary. It is an educational tool, not a diagnosis or a clinically validated estimate of disease severity.

Take the Endometriosis Quiz →

The daily foundation

One routine.
Two considered formulas.

Meet Advanced Duo ↗

Revitalizing+ in the morning. Renewal later in the day. Both belong to the main regimen, together in the white box.

Revitalizing+ in the current white-label bottle with gold cap
01 / MORNING

Revitalizing+

One capsule in the morning upon waking. A distinct blend that includes rhodiola alongside five other ingredients.

30 capsules · 30 servings

Renewal in the current white-label bottle with gold cap
02 / AFTERNOON

Renewal

One capsule in the afternoon or mid-day. A second ingredient profile that includes DIM.

30 capsules · 30 servings

We recommend allowing 3–5 months of consistent use to evaluate whether Advanced Duo fits your routine, with your clinician’s guidance. Some customers report noticing changes sooner; experiences vary and results are not guaranteed.

Follow the directions on your current packaging. Read safety considerations.

UNDERSTAND THE BIOLOGY. SUPPORT THE WOMAN.

What’s behind
the formulation?

Explore the mechanisms discussed in our research: what the ingredients are, what scientists tested, and how the findings relate to the daily duo.

Five ways to read the evidence

01

Condition biology

What published research tells us about endometriosis. Education, the key components to highlight.

02

Ingredient research

Studies of individual ingredients, with attention to the dose, preparation, and population.

03

Formulation rationale

Why ingredients were selected together. A formulation hypothesis, clearly identified as such.

04

Finished-product evidence

The exact studies and published data used in product approach and development.

05

Personal experience

Founder and customer observations. Meaningful experiences, you have a voice, it needs to be heard.

Inside the duo

Nothing to decipher.
Everything to inspect.

All seven ingredients + amounts ↗
Revitalizing+

Rhodiola rosea

125 mg per capsule

Salidroside research explores cell-stress and inflammatory signaling. See the experiments and the study settings.

Explore rhodiola →
Both formulas

Valerian root

150 mg per capsule

Explore the research on smooth-muscle activity, including an experiment with isolated human uterine tissue.

Explore valerian →
Renewal

DIM

100 mg per capsule

Discover why estrogen-receptor research depends on concentration and cell context.

Explore DIM →

These are ingredient facts and research context, not promised benefits. Read the complete Supplement Facts.

Ruby Radiance optional add-on in the black box

An optional next step

Add-on · Black box

Already have your foundation?
Meet Ruby Radiance.

Designed to complement Advanced Duo, not replace it. Keep the daily duo at the center of your routine and consider this add-on with your care team.

Explore Ruby Radiance ↗$59.97 · Sold separately
ENDOLLS / Our beginning2019

A family experience.
A reason to keep asking questions.

The people behind the formula

Personal from the start.
Accountable in the details.

Jonathon Castillo founded ENDOLLS after a family experience with endometriosis led him into research and formulation development.

That origin explains why this work matters to us. It does not replace clinical evidence. Our responsibility is to show both the thinking and its limits.

From the ENDOLLS community

Real people. Their own words.

Read customer experiences, explore their photos and videos, and hear what their routines have been like.

Individual experiences vary. Reviews describe personal experiences and are not clinical evidence.

Before you decide

Your questions belong here.

Which product should I start with?

Advanced Duo is the main ENDOLLS daily regimen: Revitalizing+ and Renewal together in the white box. Ruby Radiance is an optional add-on in the black box; it does not replace the duo.

How long does Advanced Duo last?

One set contains 30 Revitalizing+ capsules and 30 Renewal capsules. At one capsule from each bottle daily, that is a 30-day supply.

Does it treat endometriosis?

No. These are dietary supplements, not treatments or cures. No published randomized controlled trial of the exact Advanced Duo was supplied in our evidence review. Ingredient research and customer experiences do not establish a finished-product treatment effect.

What happened to the yellow bottles?

Our current Advanced Duo bottles have white labels and gold caps. They replace the earlier yellow translucent bottles. The photographs on this site show the current packaging.

Can I take it with my current care?

Do not stop or change prescribed care based on this website. Take the label to a clinician or pharmacist before use, especially if you take medicines or other supplements, have a medical condition, or have surgery planned. See the safety section for more detail.

Is a subscription required?

No. One-time purchase is the default. Where a subscription is available, its current plan and price appear beside the purchase controls. Review its renewal terms before choosing it. Existing customers can manage their subscription here.

When should I expect results?

We recommend allowing 3–5 months of consistent use to evaluate whether Advanced Duo fits your routine, with your clinician’s guidance. Some customers report noticing changes sooner; experiences vary and results are not guaranteed. Follow the label, and seek advice sooner if symptoms worsen or side effects occur.

How do shipping and returns work?

Shipping charges and available services appear at checkout. Read our shipping information and return terms before ordering. Contact ENDOLLS if you need help with an order.

Take the questions with you

A better conversation
starts with a checklist.

Label questions, evidence checks, and space to think about your current care. Yours to read and print, without an email gate.

Stay in the conversation

Occasional notes from ENDOLLS.

Product news and updates. Sign up if you would like to hear from us.

By subscribing, you agree to receive marketing emails. Unsubscribe at any time. Privacy policy.

A MORE CONSIDERED ROUTINE

Clarity first.
Then your next step.