Did COVID-19 or Vaccination Cause Endometriosis?

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Full transcript of the original video, lightly edited for readability.

So we've been getting this comment a lot. Did COVID give me endometriosis? Or could the vaccine have given me endometriosis or made it worse? Well, before we get into this discussion, please understand that the following is entirely educational content and should not be taken as medical advice. The following explanations are derived from advanced understanding of systems biology along with other disciplines. This is going to be a longer video, so if you don't have seven minutes, you may want to scroll. Now, getting into it from an anecdotal side.

During the pandemic, we actually had a lot of women reach out to us either about their endometriosis getting worse or them having acquired endometriosis when simply their family had no history of it. We had a large influx of customers as well during this time period. We also had the privilege of supporting a lot of medical professionals, such as nurses and paramedics, that had endometriosis. We help get them through the long shifts and the stressful hours thanks to our supplement. Now, that's not a promotional statement.

I, I do want you guys to understand that, that it was just predominantly a unique situation for us because we did provide a lot of structural support for many women to change the tide of, you know, the pandemic and their endometriosis. And due to all of this, we got a very unique insight that other professionals did not get. And from that, we were able to get A mass amount of data and see pattern recognition. So let's get into it. For the sake of time, we will not go super in depth.

The majority of that verbiage would be beyond the scope of this video. To address how a viral or vaccine mediated stimulus could trigger new onset endometriosis, one must first dissect the pathology of the disease. The traditional paradigm relies on Samson's theory of retrograde menstruation, where endometrial debris travels through the fallopian tubes into the peritoneum cavity. However, retrograde menstruation is a near universal phenomenon in menstruating women. Yet only approximately 10 to 20% develop clinical endometriosis. The differentiating factor lies in the immune system's ability to clear this debris.

In a healthy physiological state, peritoneal macrophages and natural killer cells identify and eliminate ectopic cells. In women who develop endometriosis, this surveillance mechanism is compromised. Endometriosis isn't just about stray cells. It's a systemic failure where the immune system stops being a janitor and starts acting like a bodyguard for the lesions. Mechanism 1. The ACE2 entry point. We know the SARS covid spike protein, whether from the virus itself or produced by your body after an M R. And a vaccine, targets the H2 receptor.

This was the primary mechanism of how the infection evolved. During the pandemic, all the talk about ACE2 was entirely focused on the lungs. However, it is also highly concentrated in the uterus and the lining of the ovaries. You see, ACE2 is a critical regulator. Of the renin angiotensin system. When the spike protein binds to these receptors, it shuts down a buffer system that normally keeps inflammation low. This leads to an accumulation of angiotensin 2, a pro inflammatory molecule that drives oxidative stress, fibrosis and dysfunctional shedding, potentially making periods heavier or more retrograde.

The binding of the spike protein leads to reduced H2 receptors on the cell surface. Case 2 is the one that breaks down angiotensin 2 into anti inflammatory variations. So having less of them. Well, I'm sure you see the issue here. Mechanism 2 the vaccine and the ovulation window. A major concern for many was the onset of symptoms, specifically after vaccination. To explain this, we look at lipid nanoparticles. Contrary to early suggestions that the vaccine stays in the localized area, pharmacokinetics and biodistribution studies show these particles travel to the liver, spleen, and significantly the ovaries and uterus.

Crucially, this accumulation increases by over 200% before, during and after ovulation because of the natural increase in blood flow to those organs. If a woman was vaccinated near her ovulatory window, her reproductive tissues may produce the spike protein locally, right in the heart of the reproductive system. This could explain the variability of why some women felt fine and others it triggered an irreversible biochemical change. Mechanism 3 the spike protein as an estrogen receptor activator. Perhaps the most groundbreaking piece of the puzzle is the estrogen receptor alpha connection.

Endometriosis is an estrogen fueled disease. It lives and breathes based on estrogen signals. The spike protein contains a specific motif, a structure that allows it to bind directly to these receptors. Specifically, a nuclear receptor CO regulator L X D like motif in the S2 subunit that allows it to bind with high affinity to estrogen receptor alpha at the activation function 2 region. Basically, put the structure in, the spike protein can aggressively bind to the estrogen receptor in a way that it produces undesirable results.

It essentially supercharges the system, telling cells to grow and survive even if actual hormone levels are normal. It also increases VEGF, the signal that tells the body to build new blood vessels to feed these lesions. Mechanism 4 molecular mimicry your immune system is designed to attack the spike protein. However, the spike protein shares blueprints with 27 different human proteins involved in making eggs and a healthy uterus. This leads to molecular mimicry. The immune system gets confused and begins a sterile inflammation attack on the reproductive tract.

This prepares the soil of the pelvic lining, making it wounded and receptive to any stray endometrial cells that want to take root. The interaction with these 27 proteins suggests that the spike protein does not merely cause general inflammation, but specifically targets the molecular machinery of the female reproductive system. If the spike protein binds to ER-alpha on the surface of stray endometrial cells, it could supercharge the growth and adhesion of Those cells triggering the necessary growth signals to transform into lesions. Mechanism 5, the oxidative storm and iron overload.

Endometriosis is fundamentally a disease of iron overload. When blood stays in the pelvic cavity, it releases iron. This triggers a toxic chemical event called the Fenton reaction. The spike protein and iron act together like gasoline on a fire. If exposed during your period, it creates an oxidative storm that damages the lining of the pelvis and provides sticky sites for new onset endometriosis. To anchor the multi hit hypothesis. For those that have been following our channel, you may be starting to see something that's becoming increasingly obvious.

Endometriosis is a network disease, not a singular pillar. It is extremely complex, more so than people realize. One, the first hit, the spike protein creates a high estrogen signaling environment. 2 the second hit, the immune system fails to clear the stray cells because it is overactivated but ineffective. 3 the third hit, molecular mimicry and iron damage prime the pelvis to accept the disease. For the women seeing their endometriosis augmented, and for those that did not have a familiar history of endometriosis but are now suffering after the pandemic, these mechanisms provide the missing link between a global viral event and their personal health reality.

We had mapped these mechanisms and more around 2022 to explain what was going on. Shortly after, a perspective study of 848 women reported that more than half, 52.6% of the participants experienced Worsened or new menstrual associated symptoms in the first cycle after receiving an M R N A. Vaccine. So to answer the question, did the COVID scenario make your endometriosis worse or trigger a new endometriosis case? Well, the mechanisms underlying all of this says that the possibility is there, so I truly hope this video answered your question.